Cannabinoid receptors are found all throughout the body, giving them a wide variety of functions. However, certain receptors are more concentrated in specific regions. CB1 receptors are abundant in the central nervous system. CB2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system.
The diversity of receptor locations shows just how important endocannabinoids are for day-to-day bodily function. They help regulate the following:
- Appetite, digestion, hunger
- Motor control
- Immune function
- Reproduction and fertility
- Pleasure and reward
- Temperature regulation
Endocannabinoids are the chemical messengers that tell your body to get these processes moving and when to stop. They help maintain optimal balance in the body, also known as homeostasis. When the ECS is disrupted, any one of these things can fall out of balance. Dysregulation in the ECS is thought to contribute to a wide variety of conditions.
The ECS theory of disease is termed “Clinical Endocannabinoid Deficiency“. The idea is simple: when the body does not produce enough endocannabinoids or cannot regulate them properly, you are more susceptible to illnesses that affect one or several of the functions listed above.